Journal article
Phenotypic and functional characteristics of highly differentiated CD57 NKG2C NK cells in HIV-1-infected individuals
AB Kristensen, KM Wragg, HA Vanderven, WS Lee, J Silvers, HE Kent, MD Grant, AD Kelleher, JA Juno, SJ Kent, MS Parsons
Clinical and Experimental Immunology | OXFORD UNIV PRESS | Published : 2022
DOI: 10.1093/cei/uxac082
Abstract
Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an individual's NK cell repertoire can be influenced by ongoing or previous viral infections. Indeed, infection with human cytomegalovirus (HCMV) drives the expansion of a highly differentiated NK cell population characterized by expression of CD57 and the activating NKG2C receptor. This NK cell population has also been noted to occur in HIV-1-infected individuals. We evaluated the NK cells of HIV-1-infected and HIV-1-uninfected individuals to determine the relative frequency of highly differentiated CD57+NKG2C+ NK cells and characterize these cells for their receptor..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council Program Grant to Stephen J Kent (APP1149990). This work was also supported by the National Institutes of Health's Office of the Director, Office of Research Infrastructure Programs (P51OD011132). Lastly, the work was supported by a K01 Award to Matthew Sidney Parsons from the National Institutes of Health's Office of the Director (K01OD031900). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.